教育经历:

1989-1993，博士，js33333金沙线路检测细胞生物学专业
1983-1986，硕士，南京农业大学组织学与胚胎学专业

工作经历:

2005 - 至今，特聘教授
2002 - 至今，js33333金沙线路检测教授
1993 - 2002，js33333金沙线路检测副教授
1999 - 2002，CRC Senior Traveling Research Fellow，英国丹迪大学.
1997 - 1999，BBSRC Senior Research Fellow，英国曼彻斯特大学
1995 - 1997，Wellcome Trust Senior Traveling Research Fellow，英国丹迪大学

社会服务工作:

国家自然科学基金委第三届和第四届生命科学部专家咨询委员会委员；
国家自然科学基金委第十一届和第十二届生命科学部专家评审组成员；
国务院学位委员会第六届和第七届学科评议组生物学组成员 ；
中国细胞生物学会资深理事；
中国生物物理学会常务理事；
中国生物物理学会第十届膜与细胞生物物理专业委员会副理事长；
教育部重点实验室主任；

荣誉奖励:

《细胞生物学》（第5版, 丁明孝，王喜忠，张传茂，陈建国 主编）获首届全国教材建设奖（高等教育类）一等奖, 2021；
《 分子细胞生物学》（第3版, 陈晔光，张传茂，陈佺 主编）获首届全国教材建设奖（高等教育类）二等奖，2021；
全国高校自然科学奖一等奖（第一完成人），2020；
科技部干细胞专项首席，2017；
js33333金沙线路检测拜耳学者奖，2015；
全国优秀科技工作者，2014；
北京市优秀博士学位论文指导教师奖；2011；
全国模范教师，2009；
北京市优秀教师，2009；
国家自然科学基金委员会“创新研究群体” I期（2005）和II期（2008）学术带头人；
国务院政府特殊津贴获得者，2008；
北京市级高等教育教学成果奖一等奖(丁明孝,陈建国,张传茂,苏都莫日根) ，2004；
《细胞生物学》全国高校精品课(丁明孝,陈建国,张传茂,苏都莫日根等），2003；
国家自然科学基金委员会“国家杰出青年科学基金”获得者，2003；
《细胞生物学》全国优秀教材奖一等奖(编者之一），2002；
中国国家自然科学奖二等奖（翟中和,张传茂,张博等七人），2001；
中国高校科学技术奖一等奖（翟中和,张传茂,张博等五人），2000；

杂志任职:

编委，Cell Research （中国），2006 - ； 编委，The Journal of Biological Chemistry，2016 - ； Associate editor，Biophysics Reports （中国），2014 - ； Review Editor，Frontiers in Cell and Developmental Biology（Switzerland），2014 -

书籍编撰:

1. 丁明孝，王喜忠，张传茂，陈建国主编，《细胞生物学》第五版， 北京，高等教育出版社，2019。 2. 陈晔光，张传茂，陈佺主编，《分子细胞生物学》第三版，北京，高等教育出版社，2019。 3. Shijiao Huang and Chuanmao Zhang, Chapter 11 The Coordination between DNA Replication Initiation and Other Cell Cycle Events. In: DNA Replication-Current Advances (Ed: Hervé Seligmann), Croatia: InTech Open Access Publisher, 2011, pp.233-252. 4. 张传茂，卢智刚，《生物膜》（杨福愉主编）第一版，第19章 Ran GTPase及其结合蛋白在核膜装配过程中的调控作用,科学出版社 2005：226-234。 5. 王喜忠，丁明孝，张传茂，杨玉华主译《分子细胞生物学》第三版，高等教育出版社，2005。原著：Gerald Karp: Cell and Molecular Biology： Concepts and Experiments (3ed). John Wiley & Sons, Inc.，2002。 6. Clarke, PR and Zhang, CM.， Chapter 11: Spatial and Temporal Control of Nuclear Envelope Assembly by Ran GTPase. In: The Nuclear Envelope (Ed: D.E. Evans, C. Huchison & J.A. Bryant), Garland Science/Bios Scienctific Publishers, 2004, pp.193-203. 7. Zhang, C., and Clarke, P. R., Chapter 5: Role of Ran GTPase in Nuclear Envelope Assembly. In Nuclear Envelope Dynamics in Embryos and Somatic Cells (Ed: Philippe Collas), Eurekah.com and Kluwer Academic/Plenum Publishers, 2002, pp.61-71.

执教课程:

细胞生物学 , 讲课 , js33333金沙线路检测 , 2002-至今，秋季
Bio2000，讲课，js33333金沙线路检测，2005 - 2016，春季
基础动物组织学，讲课，js33333金沙线路检测，2012-至今， 秋季

      本实验室主要研究方向：
　　1.干细胞增殖与分化；
　　2.细胞核结构、动态变化与功能；
　　3.细胞周期调控机理（包括纺锤体装配和核膜装配机理等）；
　　4.Ran GTP酶系统的功能调控；
　　5.肿瘤细胞增殖调控。

1. Tai L*, Zhu Y*, Ren H*, Huang X, Zhang C*, Sun F*. 8 Å structure of the outer rings of the Xenopus laevis nuclear pore complex obtained by cryo-EM and AI. Protein Cell. 2022;10.1007/s13238-021-00895-y. doi:10.1007/s13238-021-00895-y
2. Mengjie Sun, Mingkang Jia, He Ren, Biying Yang, Wangfei Chi, Guangwei Xin, Qing Jiang & Chuanmao Zhang*, NuMA regulates mitotic spindle assembly, structural dynamics and function via phase separation, NATURE COMMUNICATIONS, 2021, 12:7157 | https://doi.org/10.1038/s41467-021-27528-6.
3. Tenghan Zhuang*, Boyan Zhang, Yihong Song, Fan Huang, Wangfei Chi, Guangwei Xin, Ziyu Zhang, Steven Y. Cheng, Qing Jiang, and Chuanmao Zhang*, Sufu negatively regulates both initiations of centrosome duplication and DNA replication, PNAS, 2021, Vol. 118 No. 28 e2026421118.
4.Wangfei Chi, Gang Wang, Guangwei Xin, Qing Jiang, Chuanmao Zhang* ,PLK4-phosphorylated NEDD1 facilitates cartwheel assembly and centriole biogenesis initiations, J Cell Biol, 2021, 220 (1): e202002151. https://doi.org/10.1083/jcb.202002151
5. Qiaoyu Lin, Bin Yu, Xiangyang Wang, Shicong Zhu, Gan Zhao, Mingkang Jia, Fan Huang, Nan Xu, He Ren, Qing Jiang, and Chuanmao Zhang*, K6-linked SUMOylation of BAF regulates nuclear integrity and DNA replication in mammalian cells, PNAS, 2020,117(19): 10378-10387.
6. Guangwei Xin, Jingyan Fu, Jia Luo, Zhaoxuan Deng, Qing Jiang, and Chuanmao Zhang*, Aurora B regulates PP1γ–Repo-Man interactions to maintain the chromosome condensation state, J. Biol. Chem., 2020, 295(43) :14780–14788.
7. Boyan Zhang, Tenghan Zhuang, Qiaoyu Lin, Biying Yang, Xiaowei Xu, Guangwei Xin, Shicong Zhu, Gang Wang,Bin Yu, Tingting Zhang, Qing Jiang, and Chuanmao Zhang*, Patched1–ArhGAP36–PKA–Inversin axis determines the ciliary translocation of Smoothened for Sonic Hedgehog pathway activation, PNAS, 2019,116(3): 874-879.
8. Tingting Zhang, Guangwei Xin, Mingkang Jia, Tenghan Zhuang, Shicong Zhu, Boyan Zhang, Gang Wang, Qing Jiang and Chuanmao Zhang*，The Plk1 kinase negatively regulates the Hedgehog signaling pathway by phosphorylating Gli1，Journal of Cell Science, 2019, 132, jcs220384. doi:10.1242/jcs.220384.
9. Jia Luo, Biying Yang, Guangwei Xin, Mengjie Sun, X Boyan Zhang, Xiao Guo, Qing Jiang, and Chuanmao Zhang*, The microtubule-associated protein EML3 regulates mitotic spindle assembly by recruiting the Augmin complex to spindle microtubules, J. Biol. Chem., 2019, 294(14) 5643–5656.
10 He Ren*, Guangwei Xin*, Mingkang Jia, Shicong Zhu, Qiaoyu Lin, Xiangyang Wang, Qing Jiang, and Chuanmao Zhang*, Postmitotic annulate lamellae assembly contributes to nuclear envelope reconstitution in daughter cells. J. Biol. Chem., 2019, 294(27): 10383–10391.
11. Li Guo, Khamsah Suryati Mohd, He Ren, Guangwei Xin, Qing Jiang, Paul R. Clarke* and Chuanmao Zhang*, Phosphorylation of importin-α1 by CDK1–cyclin B1 controls mitotic spindle assembly Journal of Cell Science , 2019, 132, jcs232314. doi:10.1242/jcs.232314.
12. Fu Jingyan*, Zhang Chuanmao*, Super-resolution microscopy: successful applications in centrosome study and beyond. Biophysics Reports ,2019, 5(5-6):235-243.
13. Xiaowei Xu*, Shijiao Huang*, Boyan Zhang, Fan Huang, Wangfei Chi, Jingyan Fu, Gang Wang, Si Li , Qing Jiang and Chuanmao Zhang*, DNA replication licensing factor Cdc6 and Plk4 kinase antagonistically regulate centrosome duplication via Sas-6, Nature Communication, 2017, | 8:15164 | DOI: 10.1038/ncomms15164 |
14. Huabo Chen*, Xiaowei Xu*, Guopeng Wang*, Boyan Zhang, Gang Wang, Guangwei Xin, Junjun Liu, Qing Jiang, Hongyin Zhang and Chuanmao Zhang*, CDK4 is degraded by APC/C in mitosis and reaccumulates in early G1 phase to initiate a new cell cycle in HeLa cells, Journal of Biological Chemistry, 2017, http://www.jbc.org/cgi/doi/10.1074/jbc.M116.773226
15. Boyan Zhang, Gang Wang, Xiaowei Xu, Sisi Yang, Tenghan Zhuang, Guopeng Wang, He Ren,Steven Y. Cheng, Qing Jiang, and Chuanmao Zhang*,DAZ-interacting Protein 1 (Dzip1) Phosphorylation by Polo-like Kinase 1 (Plk1) Regulates the Centriolar Satellite Localization of the BBSome Protein during the Cell Cycle. Journal of Biological Chemistry, 2017, 292(4): 1351–1360.
16. Junjun Liu* and Chuanmao Zhang*, The equilibrium of ubiquitination and deubiquitination at PLK1 regulates sister chromatid separation, Cell. Mol. Life Sci., 2017, DOI 10.1007/s00018-017-2457-5.
17. Tan Qin, Fangjin Chen, Xiaolong Zhuo, Xiao Guo, Taikangxiang Yun, Ying Liu, Chuanmao Zhang*, and Luhua Lai* Discovery of Novel Polo-Like Kinase 1 Polo-Box Domain Inhibitors to Induce Mitotic Arrest in Tumor Cells. Journal of Medicinal Chemistry, 2016, 59: 7089−7096.
18. Wanqing Du, Qian Peter Su, Yang Chen, Yueyao Zhu, Dong Jiang, Yueguang Rong, Senyan Zhang, Yixiao Zhang, He Ren, Chuanmao Zhang, Xinquan Wang, Ning Gao, Yanfeng Wang, Lingfei Sun, Yujie Sun*, and Li Yu,* Kinesin 1 Drives Autolysosome Tubulation. Development Cell, 2016, 37( 4):326–336.
19. Xiaowei Xu, Jia Luo, Qing Jiang, and Chuanmao Zhang*, Mitotic Spindle Assembly: The Roles of Microtubule Nucleation and Assembly, 2016, In: eLS. John Wiley & Sons, Ltd:Chichester.DOI: 10.1002/9780470015902.a0022518.
20. Shijiao Huang, Xiaowei Xu, Guopeng Wang, Guoliang Lu, Wenbing Xie, Wei Tao, Hongyin Zhang, Qing Jiang, Chuanmao Zhang*, DNA replication initiator Cdc6 also regulates ribosomal DNA transcription initiation. Journal of Cell Science, 2016, 129: 1429-1440 doi:10.1242/jcs.178723.
21. Boyan Zhang, Tingting Zhang, Guopeng Wang, Gang Wang, Wangfei Chi, Qing Jiang, Chuanmao Zhang* , GSK3β-Dzip1-Rab8 Cascade Regulates Ciliogenesis after Mitosis. PLoS Biology, 2015, 13(4): e1002129. doi:10.1371/journal.pbio.1002129.
22. Jingyan Fu,* Minglei Bian,* Guangwei Xin, Zhaoxuan Deng,Jia Luo,Xiao Guo, Hao Chen,Yao Wang, Qing Jiang, and Chuanmao Zhang* , TPX2 phosphorylation maintains metaphase spindle length by regulating microtubule flux. Journal of Cell Biology, 2015, 210 (3): 373–383.
23. Xiaolong Zhuo,* Xiao Guo,* Xiaoyan Zhang, Guihua Jing, Yao Wang, Qiang Chen, Qing Jiang, Junjun Liu,* and Chuanmao Zhang* , Usp16 regulates kinetochore localization of Plk1 to promote proper chromosome alignment in mitosis. Journal of Cell Biology, 2015, 210 (5): 727–735.
24. Si Li, Zhaoxuan Deng, Jingyan Fu, Caiyue Xu, Guangwei Xin, Zhige Wu, Jia Luo, Gang Wang, Shuli Zhang, Boyan Zhang, Fangdong Zou*, Qing Jiang*, and Chuanmao Zhang*, Spatial Compartmentalization Specializes the Function of Aurora A and Aurora B. Journal of Biological Chemistry, 2015, 290(28):17546–17558.
25. Ran Q,* Nan Xu,* Gang Wang, He Ren, Si Li, Jun Lei, Qiaoyu Lin, LihaoWang, Xin Gu, Hongyin Zhang, Qing Jiang,* and Chuanmao Zhang* , The lamin-A/C–LAP2–BAF1 protein complex regulates mitotic spindle assembly and positioning. Journal of Cell Science, 2015, 128: 2830-2841.
26. Wu, Yiran、Zhuo, Xiaolong、Dai, Ziwei、Guo, Xiao、Wang, Yao、Zhang, Chuanmao*、Lai, Luhua*，Modeling the mitotic regulatory network identifies highly efficient anti-cancer drug combinations. Mol Biosyst, 2015, 11(2): 497-505.
27. Zhang, Meiling; Sun, Tao; Jian, Chongshu; Lei, Lei; Han, Peidong; Lv, Quanlong; Yang, Ran; Zhou, Xiaohai; Xu, Jiejia; Hu, Yingchun; Men, Yongfan; Huang, Yanyi; Zhang, Chuanmao; Zhu, Xiaojun; Wang, Xianhua; Cheng, Heping; Xiong, Jing-Wei* , Remodeling of Mitochondrial Flashes in Muscular Development and Dystrophy in Zebrafish. PLos One, 2015, 10(7), p e0132567.
28. Gang Wang, Qing Jiang and Chuanmao Zhang*, The role of mitotic kinases in coupling the centrosome cycle with the assembly of the mitotic spindle. Journal of Cell Science, 2014,127:4111-4122.
29. Han, Peidong;Zhou, Xiao-Hai;Chang, Nannan;Xiao, Cheng-Lu;Yan, Shouyu;Ren, He;Yang, Xin-Zhuang;Zhang, Mei-Ling;Wu, Qing;Tang, Boyang;Diao, Ju-Peng;Zhu, Xiaojun;Zhang, Chuanmao;Li, Chuan-Yun;Cheng, Heping;Xiong, Jing-Wei*, Hydrogen peroxide primes heart regeneration with a derepression mechanism. Cell Research, 2014, 24(9),1091-1107.
30. Zhige Wu, Qing Jiang, Paul R. Clarke* and Chuanmao Zhang*, Phosphorylation of Crm1 by CDK1–cyclin-B promotes Ran-dependent mitotic spindle assembly, Journal of Cell Science, 2013, 126 (15)：3417–3428.
31. Gang Wang, Qiang Chen, Xiaoyan Zhang, Boyan Zhang, Xiaolong Zhuo, Junjun Liu, Qing Jiang and Chuanmao Zhang*, PCM1 recruits Plk1 to the pericentriolar matrix to promote primary cilia disassembly before mitotic entry, Journal of Cell Science, 2013, 126 (6)： 1355–1365.
32. Wenxiang Fu, Hao Chen, GangWang, Jia Luo, Zhaoxuan Deng, Guangwei Xin, Nan Xu, Xiao Guo, Jun Lei, Qing Jiang and Chuanmao Zhang*, Self-assembly and sorting of acentrosomal microtubules by TACC3 facilitate kinetochore capture during the mitotic spindle assembly, Proc. Natl. Acad. Sci. USA (PNAS), 2013, 110 (38) : 15295–15300.
33. Quanlong Lu, Zhigang Lu, Qinying Liu , Li Guo, He Ren, Jingyan Fu, Qing Jiang, Paul R Clarke, Chuanmao Zhang*, Chromatin-bound NLS proteins recruit membrane vesicles and nucleoporins for nuclear envelope assembly via importin-α/β. Cell Research, 2012, 22:1562-1575.
34. Yueguang Rong; Yuan Tian; Jianzhong Xi; Chuanmao Zhang; Hanshuo Zhang; Zhen Cao; She Chen; Wanqing Du; Lin Li; Ying Li; Mei Liu; Liang Ma; He Ren; Li Yu*, Clathrin and phosphatidylinositol-4,5-bisphosphate regulate autophagic lysosome reformation. Nature Cell Biology, 2012, 14(9):924-934.
35. Shiqi Wang; Weiming Xiao; Chuanmao Zhang; Yan Zhang; Juan Chen; Ming Chen; Quan Chen; Chunsun Jiang; Shouqin Lü; Sicong Shan; Mian Long*, Multi-patterned dynamics of mitochondrial fission and fusion in a living cell. PloS one, 2012, 7(5):e19879.
36. Hao-Di Wu, Ming Xu, Rong-Chang Li, Liang Guo, Ying-Si Lai, Shi-Ming Xu,Su-Fang Li, Quan-Long Lu , Lin-Lin Li, Hai-Bo Zhang, You-Yi Zhang, Chuan-Mao Zhang, and Shi-Qiang Wang*, Ultrastructural remodelling of Ca21 signalling apparatus in failing heart cells. Cardiovascular Research, 2012, 95, 430–438.
37. Wenxiang Fu, Qing Jiang and Chuanmao Zhang*, Novel functions of endocytic player clathrin in mitosis. Cell Research, 2011, 21:1655-1661.
38. Xiu-Hua Xue, Chun-Qing Guo, Fei Du, Quan-Long Lu, Chuanmao Zhang and Hai-Yun Ren*, AtFH8 Is Involved in Root Development under Effect of Low-Dose Latrunculin B in Dividing Cells. Molecular Plant, 2011, 4（2）：264–278.
39. Fu, J., Jiang, Q. & Zhang, C., Coordination of Cell Cycle Events by Ran GTPase. Nature Education ,2010, 3(9):32.
40. Fu, J., Jiang, Q. & Zhang, C., Collaboration of Mitotic Kinases in Cell Cycle Control. Nature Education, 2010, 3(9):82.
41. BIAN MingLei, FU JingYan, YAN Y, JIANG Qing, and ZHANG ChuanMao*, Short Exposure to Paclitaxel Induces Multi-polar Spindle Formation and Aneuploidy through Promoting Acentrosomal Pole Assembly, CHINESE SCI BULL, 2010, 53（11）：1322-1329.
42. Xuelong Lu, Yang Shi, Quanlong Lu, Yan Ma, Jia Luo, Qingsong Wang, Jianguo Ji, Qing Jiang and Chuanmao Zhang*, Requirement for lamin B receptor and its regulation by importin β and phosphorylation in nuclear envelope assembly during mitotic exit, J Biol Chem., 2010, 285: 33281–33293.
43. Wenxiang Fu, Wei Tao, Puwei Zheng, Jingyan Fu, Minglei Bian, Qing Jiang, Paul R Clarke and Chuanmao Zhang*, Clathrin recruits phosphorylated TACC3 to spindle poles for bipolar spindle assembly and chromosome alignment. Journal of Cell Science, 2010, 123, 3645-3651.
44. Qinying Liu, Jingying Yu, Xiaolong Zhuo, Qing Jiang and Chuanmao Zhang*， Pericentrin contains five NESs and an NLS essential for its nucleocytoplasmic trafficking during the cell cycle, Cell Research, 2010, 20:948–962.
45. Zhang J, Liu W, Liu J, Xiao W, Liu L, Jiang C, Sun X, Liu P, Zhu Y, Zhang C, Chen Q. G-protein β2 subunit interacts with mitofusin 1 to regulate mitochondrial fusion. Nat Commun. 2010 Oct 19;1:101. doi: 10.1038/ncomms1099.
46. Qinying Liu, Qing Jiang and Chuanmao Zhang*, A fraction of Crm1 locates at centrosomes by its CRIME domain and regulates the centrosomal localization of pericentrin. Biochemical and Biophysical Research Communications, 2009, 384: 383-388.
47. Xiaoyan Zhang, Qiang Chen, Jia Feng, Junjie Hou, Fuquan Yang, Junjun Liu, Qing Jiang and Chuanmao Zhang*, Sequential phosphorylation of Nedd1 by Cdk1 and Plk1 is required for targeting of the γTuRC to the centrosome, Journal of Cell Science, 2009,122, 2240-2251.
48. Jingyan Fu, Minglei Bian, Junjun Liu, Qing Jiang, and Chuanmao Zhang*, A single amino acid change converts Aurora-A into Aurora-B-like kinase in terms of partner specificity and cellular function. Proc. Natl. Acad. Sci. USA (PNAS), 2009, 106 (17): 6939–6944.
49. Fei Lu, Rongfeng Lan, Hongyin Zhang, Qing Jiang, and Chuanmao Zhang*., Geminin is partially localized to centrosome and plays a role in proper centrosome duplication. Biology of the Cell Decision Letter, 2009, 101, 273–285.
50. Yan Ma, Shang Cai, Quanlong Lu, Xuelong Lu, Qing Jiang, Jun Zhou and Chuanmao Zhang*, Inhibition of Deacetylation Impairs Microtubule-kinetochore Attachment through Interfering with Kinetochore Integrity, Centromere Function and Microtubule Behavior. Cellular and Molecular Life Sciences, 2008, 65：3100-3109.
51. Clarke PR and Zhang CM., Spatial and temporal coordination of mitosis by Ran GTPase. Nature Review Molecular Cell Biology, 2008, 9: 467-477.
52. Qiang Chen, Xiaoyan Zhang, Qing Jiang, Paul Clarke, and Chuanmao Zhang*, Cyclin B1 is localized to unattached kinetochores and is required for chromosome alignment during mitosis. Cell Research, 2008, 18: 268-280.
53. Lei Sun , Dengwen Li, Xin Dong , Haiyang Yu , Jin-Tang Dong ,Chuanmao Zhang , Xianyu Lu , Jun Zhou*, Small-molecule inhibition of Aurora kinases triggers spindle checkpoint-independent apoptosis in cancer cells. Biochemical Pharmacology, 2008, 75: 1027–1034.
54. Long Zhao, Xinyi Zhao, Tian Tian, Quanlong Lu, Nirma Skrbo-Larssen ,DiWu, Zheng Kuang，Xiaofeng Zheng, Yanchao Han, Shuyan Yang, Chuanmao Zhang, and Anming Meng*, Heart-specific isoform of tropomyosin4 is essential for heartbeat in zebrafish embryos. Cardiovascular Research, 2008, 80:200-208.
55. Yan Ma, Shang Cai, Quanlong Lv, Xuelong Lv, Quan Zhang, Qing Jiang, Sodmergen，Zhonghe Zhai and Chuanmao Zhang*., Lamin B receptor plays a role in stimulating nuclear envelope production and targeting membrane vesicles to chromatin during nuclear envelope assembly through direct interaction with importin β. Journal of Cell Science, 2007, 120: 520-530.
56. Jingyan Fu，Minglei Bian，Qing Jiang and Chuanmao Zhang*, Roles of Aurora Kinases in Mitosis and Tumorigenesis. Molecular Cancer Research. 2007, 5(1). 1-10.
57. Xiaofeng Zheng, Xueyu Dai, Yanmei Zhao, Qiang Chen, Fei Lu, Deqiang Yao, Quan Yu, Xinping Liu, Chuanmao Zhang, Xiaocheng Gu, and Ming Luo*, Restructuring of the dinucleotide-binding fold in an NADP(H) sensor protein. Proc. Natl. Acad. Sci. USA (PNAS), 2007, 104（21）：8809–8814
58. Zhe Liu, Hao Lin, Sheng Ye, Qin-ying Liu, Zhaohui Meng, Chuanmao Zhang, Yongjing Xia, Emanuel Margoliash, Zihe Rao, and Xiang-jun Liu*, Remarkably high activities of testicular cytochrome c in destroying reactive oxygen species and in triggering apoptosis. Proc. Natl. Acad. Sci. USA (PNAS), 2006, 103: 8965–8970.
59. Chen Z, Cai S, Jiang Q, Zhang C* & Tang X., Roles for microtubule and microfilament cytoskeletons in animal cell cytokinesis. Chinese Science Bulletin., 2005, 50: 229-235
60. Zhigang Lu, Chuanmao Zhang*, and Zhonghe Zhai*, Nucleoplasmin regulates chromatin condensation during apoptosis. Proc. Natl. Acad. Sci. USA (PNAS), 2005, 102: 2778-2783.
61. Hui Ren, Liya Wang, Matthew Bennett, Yuhe Liang, Xiaofeng Zheng, Fei Lu, Lanfen Li, Jie Nan, Ming Luo, Staffan Eriksson, Chuanmao Zhang, and Xiao-Dong Su., The Crystal Structure of human Adenylate Kinase 6: An Adenylate Kinase Localized to the Cell Nucleus. Proc. Natl. Acad. Sci. USA (PNAS) ,2005, 102:303-308.
62. Qing Jiang, Zhigang Lu and Chuanmao Zhang*. Roles of Ran GTPase in the Cell Cycle Regulation coordination. CHINESE SCI BULL, 2004, 49（6）:535-541.
63. Zhigang Lu, Chuanmao Zhang* and Zhonghe Zhai*, LDFF, the large molecular weight DNA fragmentation factor, is responsible for the large molecular weight DNA degradation during apoptosis in Xenopus egg extracts. Cell Research, 2004, 14:134-140.
64. Yang N, Chen ZC, Lu P, Zhang CM (Corresponding Author), Zhai ZH*, Tang XW*. The microtubule aster formation and its role in nuclear envelope assembly around the sperm chromatin in Xenopus egg extracts. CHINESE SCI BULL，2003，48 (18): 1912-1918.
65. William J. Moore, Chuanmao Zhang, and Paul R. Clarke*, Targeting of RCC1 to Chromosomes Is Required for Proper Mitotic Spindle Assembly in Human Cells. Current Biology, 2002, 12, 1442–1447.
66. Zhang, C., Goldberg, M., Moor, W., Allen, T. D., and Clarke, P. R.*, Concentration of Ran on chromatin induces decondensation, nuclear envelope formation and nuclear pore complex assembly. European J. Cell Biol., 2002, 81 (11): 623-633.
67. Zhang, C., Hutchins, JR, Mulhausser, P, Kutay, U., mand Clarke, P. R.*, Role of Importin β in the Control of Nuclear Envelope Assembly by Ran. Current Biology, 2002, 12: 498-502.
68. Clarke, PR and Zhang C., Ran GTPase: a master regulator of nuclear structure and function during the eukaryotic cell division cycle? Trends in Cell Biol., 2001,11:366-371.
69. Zhang, C., and Clarke, P. R., The roles of RanGDP and RanGTP in precursor vesicle recruitment and fusion during nuclear envelope assembly in a human cell-free system. Current Biology, 2001, 11:208-212.
70. Zhang, C.*, and Clarke, P. R.*, Chromatin-independent Nuclear Envelope Assembly induced by RanGTPase in Xenopus Egg Extracts. Science, 2000, 288:1429-1432.
71. Zhang, C., Hughes, M., Clarke, P. R.*, Ran-GTP stablises microtubule asters and inhibits nuclear assembly in Xenopus egg extracts. Journal of Cell Science, 1999, 112: 2453-2461.
72. Hughes, M., Zhang, C (Co-first Author), Avis, J. M., Hutchison, C. J, Clarke, P. R.*,The role of the Ran GTPase in nuclear assembly and DNA replication: Characterization of the effects of Ran mutants. Journal of Cell Science, 1998, 111:3017-3026.
73. Nicholas, F., Zhang, C., Hughes, M., Goldberg, M., Clarke, P.*, Xenopus Ran-binding protein 1: molecular interactions and effects on nuclear assembly in Xenopus egg extracts. Journal of Cell Science, 1997, 110:3019-3030.
74. Zhang, Chuanmao., Gordberg, M. W., Allen, T.D., and Hutchison, C. J.*, Nuclear lamina and nuclear matrix organization in sperm pronuclei assembled in Xenopus egg extract. Journal of Cell Science, 1996, 109: 2275-2286.

I.  本实验室长期以来主要以细胞生物学、分子生物学和生物化学等为研究手段，在分子水平、细胞和亚细胞水平以及组织和个体水平上，从事干细胞增殖与分化、细胞周期调控、细胞核结构和动态变化及功能、Ran GTP酶功能调控等方面的研究。实验材料主要包括：培养细胞，小鼠，非洲爪蟾，果蝇等。

II.  已取得如下主要成绩： 

1，发现Ran GTPase 控制核膜装配(Science, 2000; Curr Biol, 2011; J Cell Sc, 2012）。
2，发现Ran GTPase 控制纺锤体组装(J Cell Sci, 1999)。 
3，建立了应用相关蛋白质小球和细胞(包括卵细胞)提取物为材料的非细胞体系核膜重建模式(Curr Biol, 2001, 2002; Eur J Cell Biol,2002）。
4，发现核膜物质运输相关蛋白importin alpha和beta 参与核膜装配(Curr Biol, 2002；Cell Res，2012)。
5，发现Ran 调控核孔复合体装配(Eur J Cell Biol, 2002；Cell Res，2012)。
6，发现RCC1在染色体上定位所产生的Ran-GTP梯度是纺锤体正确装配所需要的(Curr Biol, 2002)。
7，发现Ran GTPase 通过调控核膜物质运输进而调控DNA 复制(J Cell Sci,1998)。
8，以实验证明细胞核纤层(Nuclear lamina)对细胞核结构的维持和DNA 复制起重要调控作用(J Cell Sci,1996)。
9，发现Nucleoplasin在非洲爪蟾卵提取物细胞凋亡过程中调控染色质的凝集(PNAS，2005)。

10，发现Aurora A/B, Plk1, Cdk1等激酶综合调控纺锤体装配(PNAS，2009，2013；Cell Res, 2008, 2011; J Cell Sci, 2009, 2013a, 2013b)。 

11，发现CDK1, Aurora A/B和TPX2等综合调控纺锤体装配的新机制（J Cell Biol, 2015a; J Cell Sci, 2015；J Biol Chem, 2015)。

12, 发现去泛素化酶Ups16和Plk1综合调控动粒与纺锤体微管的结合及纺锤体装配的调控机制（J Cell Biol，2015b；CMLS，2017）。

13，发现细胞周期调控因子调控初级纤毛动态变化及其细胞信号转导功能（J Cell Sci, 2013， 2014；PLoS Biol, 2015; J Biol Chem, 2017a）。

14，发现DNA复制起始调控因子CDC6调控rDNA转录的新机制（J Cell SCI，2016）和调控中心体复制的新机制（NatureCommunications，2017）。

15，发现CDK4-Cyclin D1激酶调控细胞周期起始的新机制（J Biol Chem，2017b）。

III.  在研经费主要来源：科技部干细胞专项；科技部蛋白质机器专项；基金委重点课题；基金委重大国际合作等。

IV.   热烈欢迎有志从事相关基础研究的优秀博士后、博士研究生和本科生加盟。