教育经历:
1995-1999,博士,英国剑桥大学、MRC分子生物学实验室 (细胞生物学)
1992-1995,学士,英国剑桥大学、三一学院 (自然科学)
工作经历:
2019-至今,教授,js33333金沙线路检测
2019-至今,研究员,js33333金沙线路检测-清华大学生命科学联合中心
2019-至今,研究员,js33333金沙线路检测麦戈文脑科学研究所
2019-至今,主任,js33333金沙线路检测医学部孤独症研究中心
2005-2019,研究员,中国科学院神经科学研究所
1999-2005,博士后,美国斯坦福大学医学中心
荣誉奖励:
2022, “长江学者奖励计划”特聘教授
2020,北脑学者
2019,张香桐神经科学青年科学家奖
2018,“万人计划”科技创新领军人才
2017,中国科学院优秀研究生指导教师
2017,上海领军人才
2016,上海市优秀学术带头人
2016,中青年科技创新领军人才
2014,第七届上海青年科技英才(基础研究类)
2014,第十一届中国青年女科学家奖
2012,中国科学院优秀研究生指导教师
2011,国家杰出青年科学基金
2005,中国科学院百人计划
2005,Grass Fellow, Marine Biological Laboratory, Woods Hole, MA.
1999,Wellcome Prize Travelling Research Fellowship
学术任职:
2022-今 北京市实验动物专家委员会副主任委员
2022-今 国际孤独症研究学会(INSAR)科学标注委员会成员
2022-2023 国际脑研究组织(IBRO)日程委员会成员
2021-今 北京神经科学学会第十届监事会成员
2021-今 美国神经科学学会 (SfN) Peter Seeburg 综合神经科学奖评委会委员
2020-今 中国神经科学学会儿童认知与脑功能障碍分会副主任委员
2020-今 中国神经科学学会神经发育与再生分会委员
2019-今 美国神经科学学会 (SfN) 日程委员会成员
杂志任职:
2023- ,Neuron,编委
2022- ,《中国科学:生命科学》,编委
2022- ,National Science Review ,生命学科编辑工作组
2021- ,eLife,编委
2020- ,Autism Research,编委
2019- ,Journal of Cell Biology,编委
2017- ,Developmental Neurobiology,编委
2014- ,Frontiers in Cellular Neuroscience,编委执教课程:
神经发育与可塑性 (秋季,主讲,本研合上)
心理/神经/脑科学基础(秋季,主讲,研究生)
现代生物学基础理论(春季,参与,研究生)
实验动物使用基础(秋季,主持,研究生) 调控神经环路发育与可塑性的分子环路机制
大脑的正常认知功能依赖于其复杂而精细的神经网络。来自环境的刺激对大脑中神经元的生长、突触的形成,以及神经环路的建立至关重要。在调控神经环路发育与可塑性的机制方面,本团队近期成果包括:1. 发现早期感觉经验跨模态调节多个脑区的神经环路发育,且神经肽催产素是关键介导分子;2. 揭示了早期抚摸促进愉悦社交的神经环路机制,并阐明了PAG脑区Tac1神经元和室旁核催产素神经元在该环路中的重要作用;3. 发现系统感染早期,脑血管周细胞快速感应,并通过释放细胞因子CCL2增强多个脑区神经元的兴奋性;4 发现神经环路成熟期,感觉皮层的树突棘修剪和被保留树突棘的成熟受感觉经验协同调控,且树突棘之间对cadherin/catenin复合物这个有限资源的竞争介导了该过程。
基于上述结果,我们提出了“早期神经环路跨模态全局发育假说”。 发育早期的大脑具有更高的可塑性——且部分脑功能具有关键期——是神经科学公认的现象,然而介导这些过程的机制仍不很清楚。本团队结合单细胞表达谱分析、分子生物学、遗传学、免疫组化等方法,解析介导该过程的分子机制;还运用电生理、光学成像、行为学等方法研究感觉经验与环境因素对发育早期神经元、胶质细胞和神经血管单元的调控,以期解析介导该可塑性的细胞与环路机制。解析幼年大脑发育早期跨模态可塑性的机制对理解大脑的工作原理有重要理论意义。孤独症谱系障碍、智力障碍等发育性神经系统疾病严重影响儿童健康。通过解析幼年大脑的工作原理,在发育早期给予有遗传风险的个体促进其大脑发育的个体化药物治疗与行为干预,有潜在的临床应用意义。
关键词:神经发育、神经环路发育、突触可塑性、孤独症、自闭症
1. Li H., Jiang T., An S., Xu M., Gou L., Ren B., Shi X., Wang X., Yan J., Yuan J., Xu X., Wu Q.F., Luo Q., Gong H., Bian W.J.* Li A.*, Yu X.* (2024) Single-neuron projectomes of mouse paraventricular hypothalamic nucleus oxytocin neurons reveal mutually exclusive projection patterns. Neuron 112(7):1081-1099.
2. Duan L.* and Yu X.* (2024) Fibroblasts: New players in the central nervous system? Fundam. Res. 4(2):262-266.
3. Wang M.* and Yu X.* (2023) Experience-dependent structural plasticity of pyramidal neurons in the developing sensory cortices. Curr. Opin. Neurobiol. doi: 10.1016/j.conb.2023.102724
4. Li G.Y.*, Wu Q.Z., Song T.J., Zhen X.C., Yu X.* (2023) Dynamic regulation of excitatory and inhibitory synaptic transmission by growth hormone in the developing mouse brain. Acta Pharmacol. Sin. 44(6):1109–1121.
5. Yu H., Miao W., Ji E., Huang S., Jin S., Zhu X., Liu M.Z., Sun Y.G., Xu F., and Yu X.* (2022) Social touch-like tactile stimulation activates a tachykinin 1-oxytocin pathway to promote social interactions. Neuron 110(6):1051-1067. (highlighted by same issue Preview 110(6):909-911)
6. Yu X.* (2021) Q&A Xiang Yu. Neuron 109(19):3022-3024.
7. Cao H., Li M.Y., Li G., Li S.J., Wen B., Lu Y., and Yu X.* (2020) Retinoid X receptor α regulates DHA-dependent spinogenesis and functional synapse formation in vivo. Cell Rep. 31(7):107649.
8. Wang M., Yu Z., Li G., and Yu X.* (2020) Multiple morphological factors underlie experience-dependent cross-modal plasticity in the developing sensory cortices. Cereb. Cortex, 30(4):2418–2433.
9. Duan L., Zhang X.D., Miao W.Y., Sun Y.J., Xiong G., Wu Q., Li G., Yang P., Yu H., Li H., Wang Y., Zhang M., Hu L.Y., Tong X., Zhou W.H., Yu X.* (2018) PDGFRβ cells rapidly relay inflammatory signal from the circulatory system to neurons via chemokine CCL2. Neuron 100(1):183-200. (highlighted by same issue Preview 100(1):11-13)
10. Hu C.C., Xu X.*, Xiong G.L., Xu Q., Zhou B.R., Li C.Y., Qin Q., Liu C.X., Li H.P., Sun Y.J.*, Yu X.* (2018) Alterations in plasma cytokine levels in Chinese children with autism spectrum disorder. Autism Res. 11(7):989-999.
11. Li M.Y., Miao W.Y., Wu Q.Z., He S.J., Yan G., Yang Y., Liu J.J., Taketo M.M. and Yu, X.* (2017) A critical role of presynaptic Cadherin/Catenin/p140cap complexes in stabilizing spines and functional synapses in the neocortex. Neuron 94(6):1155-1172
12. Wang L., Li M.Y., Qu C., Miao W.Y., Yin Q, Liao J., Cao H.T., Huang M., Wang K., Zuo E., Peng G., Zhang S.X., Chen G., Li Q., Tang K., Yu Q., Li Z., Wong CCL, Xu G., Jing N., Yu X.*, and Li J*. (2017) CRISPR-Cas9-mediated genome editing in one blastomere of two-cell embryos reveals a novel Tet3 function in regulating neocortical development. Cell Res. 27(6):815-829
13. Wang M., Li H., Takumi T., Qiu Z., Xu X.*, Yu X.* and Bian W.J.* (2017) Distinct Defects in Spine Formation or Pruning in Two Gene Duplication Mouse Models of Autism Neurosci. Bull. 33(2):143-152
14. Zhang S.X., Duan L.H., He S.J., Zhuang G.F. and Yu X.* (2017) Phosphatidylinositol 3,4-bisphosphate regulates neurite initiation and dendrite morphogenesis via actin aggregation. Cell Res. 27(2):253-273.
15. Bian W.J., Miao W.Y., He S.J., Qiu Z. and Yu, X.* (2015) Coordinated spine pruning and maturation mediated by inter-spine competition for cadherin/catenin complexes. Cell 162(4): 808-822 [highlighted by Nat. Rev. Neurosci. 16(10):577; selected as “exceptional” by Faculty 1000]
16. Zheng J.J., Li S.J., Zhang X.D., Miao W.Y., Zhang D., Yao H. and Yu, X.* (2014) Oxytocin mediates early experience–dependent cross-modal plasticity in the sensory cortices. Nat. Neurosci. 17(3):391-399 [highlighted by same issue News and Views 17(3), 340 and by Nat. Rev. Neurosci. 15(3):139; selected as “exceptional” by Faculty 1000]
17. Xu X.*, Xu Q., Zhang Y., Zhang X., Cheng T., Wu B., Ding Y., Lu P., Zheng J., Zhang M., Qiu Z., and Yu X.* (2012) A case report of Chinese brothers with inherited MECP2-containing duplication: autism and intellectual disability, but not seizures or respiratory infections. BMC Med. Genet. 13(1):75 doi:10.1186/1471- 2350-13-75
18. Peng Y.R., Zeng S.Y., Song H.L., Li M.Y., Yamada M.K., and Yu X.* (2010) Postsynaptic spiking homeostatically induces cell-autonomous regulation of inhibitory inputs via retrograde signaling J. Neurosci. 30(48):16220-16231, cover story.
19. He S., Ma J., Liu N. and Yu, X.* (2010) Early enriched environment promotes neonatal GABAergic neurotransmission and accelerates synapse maturation. J. Neurosci. 30(23):7910-7916.
20. Tan Z.J., Peng Y., Song H.L. and Yu X.* (2010) N-cadherin dependent neuron-neuron interaction is required for the maintenance of activity-induced dendrite growth. Proc. Natl. Acad. Sci. USA 107(21):9873-9878, cover story.
21. Peng Y.R., He S., Marie H., Zeng S.Y., Ma J., Tan Z.J., Lee S., Malenka R.C.*, and Yu X.* (2009) Coordinated changes in dendritic arborization and synaptic strength during neural circuit development. Neuron 61(1):71-84. (Selected by Faculty 1000).
22. Yu X.* and Malenka R.C.* (2003) β¬-catenin is critical for dendritic morphogenesis. Nat. Neurosci. 6(11): 1169-¬1177, cover story.